The fixed-dose combination of sofosbuvir-ledipasvir provides an effective and well-tolerated one-pill once-a-day option for treatment of genotypes 1, 4, 5, and 6 chronic hepatitis C (HCV) infection.
This direct-acting antiviral regimen was the first FDA-approved interferon- and ribavirin-free regimen to treat hepatitis C. Ledipasvir-sofosbuvir can be used without ribavirin in most patients with genotype 1A, except those who are cirrhotic and treatment-experienced.
In addition, patients who are treatment-naïve, not black, and without cirrhosis may be eligible for an 8-week duration which has been found in clinical trials and observational studies to be as effective as 12 weeks. Like sofosbuvir-velpatasvir, the other NS5B-NS5A inhibitor combination, it has been shown to be safe and efficacious in patients with decompensated cirrhosis.
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